Reynolds M L, Møllgård K, Saunders N R
Anat Embryol (Berl). 1983;168(2):227-40. doi: 10.1007/BF00315818.
The distribution of the five plasma proteins that are quantitatively most important during development in the sheep has been studied in embryos of 15 to 21 days gestation. The three primary embryonic layers and tissues that differentiate from them were tested for the presence of alpha-fetoprotein (AFP), fetuin, albumin, transferrin and alpha 1-antitrypsin using the indirect immunoperoxidase method. Fetuin was the most prominent of these proteins particularly in the developing central nervous system. Fetuin and transferrin appeared early in the differentiating mesoderm and, with albumin and AFP, were detected in tissues originating from all three layers during the course of development. alpha 1-Antitrypsin appeared to have a limited distribution. All five plasma proteins were detected before the establishment of a circulatory system. It is suggested that their appearance in embryonic tissue is related to its stage of development and that they play an important part in early differentiation.
对妊娠15至21天绵羊胚胎中发育过程中数量上最重要的五种血浆蛋白的分布进行了研究。使用间接免疫过氧化物酶法，对三个主要胚胎层以及由它们分化而来的组织进行检测，以确定是否存在甲胎蛋白（AFP）、胎球蛋白、白蛋白、转铁蛋白和α1抗胰蛋白酶。胎球蛋白是这些蛋白质中最突出的，尤其是在发育中的中枢神经系统中。胎球蛋白和转铁蛋白在分化中的中胚层中出现较早，并且与白蛋白和甲胎蛋白一起，在发育过程中从所有三层起源的组织中都被检测到。α1抗胰蛋白酶的分布似乎有限。在循环系统建立之前就检测到了所有五种血浆蛋白。有人提出，它们在胚胎组织中的出现与其发育阶段有关，并且它们在早期分化中起重要作用。
