Scamurra D O, Davey F R, Nelson D A, Kurec A S, Goldberg J
Ann Clin Lab Sci. 1983 Nov-Dec;13(6):496-502.
A case is described of acute leukemia whose neoplastic cells possessed myeloid and lymphoid characteristics. Neoplastic cells possessed cytoplasmic granules containing Sudan black B material and diaminobenzidine myeloperoxidase. In addition, these luekemic cells were positive for terminal deoxynucleotidyl transferase. Ia antigen, and the common acute lymphocytic leukemia antigen. These findings indicate that biphenotypic cell markers may exist in cases of acute leukemia. It is our belief that these results are best explained as either a mixed myeloid-lymphoid leukemia or a stem cell leukemia capable of differentiating into myeloid and lymphoid cells.
本文描述了一例急性白血病病例，其肿瘤细胞具有髓系和淋巴系特征。肿瘤细胞含有含苏丹黑B物质和二氨基联苯胺髓过氧化物酶的细胞质颗粒。此外，这些白血病细胞末端脱氧核苷酸转移酶、Ia抗原和常见急性淋巴细胞白血病抗原呈阳性。这些发现表明急性白血病病例中可能存在双表型细胞标志物。我们认为，这些结果最好解释为混合性髓系-淋巴系白血病或能够分化为髓系和淋巴系细胞的干细胞白血病。
