Rosen P P
Ann Surg. 1978 Jan;187(1):17-9. doi: 10.1097/00000658-197801000-00004.
Experiences with frozen sections performed on 556 consecutive breast biopsies were reviewed. There were no false positive reports among the 145 (26%) lesions interpreted as carcinoma. Among 381 (68.6%) biopsies in which no carcinoma was found on frozen section, eight proved to contain carcinoma in other areas. Seven of the false negatives contained noninvasive carcinoma (six--in situ lobular; 1--intraductal). A small infiltrating lesion was found in the eighth case. The diagnosis was deferred to paraffin section in 30 (5.4%) of biopsies. Ten lesions proved to be noninvasive carcinoma and one was an infiltrating lobular carcinoma. Frozen section diagnosis is a highly reliable procedure for the diagnosis of infiltrating breast carcinoma. Noninvasive carcinoma may be overlooked at frozen section because of the limitations of sampling. Consequently, patients should be cautioned to await the paraffin section report if the frozen section does not reveal carcinoma. A frozen section diagnosis of carcinoma does not necessarily commit the surgeon to further surgery at that time and the information obtained from the frozen section may be helpful in beginning to plan further treatment with the patient.
回顾了对556例连续乳腺活检进行冰冻切片检查的经验。在145例（26%）被诊断为癌的病变中，没有假阳性报告。在381例（68.6%）冰冻切片未发现癌的活检中，有8例在其他区域被证实含有癌。8例假阴性中有7例为非浸润性癌（6例小叶原位癌；1例导管内癌）。第8例发现一个小的浸润性病变。在30例（5.4%）活检中，诊断被推迟到石蜡切片。10例病变被证实为非浸润性癌，1例为浸润性小叶癌。冰冻切片诊断对浸润性乳腺癌的诊断是一种高度可靠的方法。由于取材的局限性，非浸润性癌在冰冻切片时可能被漏诊。因此，如果冰冻切片未发现癌，应告知患者等待石蜡切片报告。冰冻切片诊断为癌并不一定意味着外科医生此时就要进行进一步手术，从冰冻切片获得的信息可能有助于开始为患者规划进一步的治疗。
