Webber B M
J Surg Oncol. 1976;8(3):191-5. doi: 10.1002/jso.2930080302.
Patients with breast cancer who have clinically negative axillae, tumors 2 cm in diameter or less, and tumors with a moderate or low degree of anaplasticity are candidates for treatment by local excision and irradiation. A definitive histologic diagnosis should be made in all cases of breast cancer before a final treatment decision is made. This can be accomplished by needle or excisional biopsy. After a histologic diagnosis is established, the decision regarding treatment can be arrived at with the patient enering into the process. Those patients requiring mastectomy will be better able to cope with this, knowing why the operation was considered best for them. The elimination of frozen section diagnosis will free the patient from one of the great fears of the current treatment of breast cancer- subjecting herself to biopsy without knowing what the outcome will be. It will free the surgeon from the rigid sequence of frozen section followed by mastectomy and allow him to begin to rationally assign patients with proper criteria to conservative treatment, reserving mastectomy for those who do not meet these criteria.
临床腋窝阴性、肿瘤直径2厘米或更小且间变程度为中度或低度的乳腺癌患者适合接受局部切除和放疗。在做出最终治疗决定之前，所有乳腺癌病例均应做出明确的组织学诊断。这可以通过针吸活检或切除活检来完成。建立组织学诊断后，可让患者参与进来，共同做出治疗决定。那些需要进行乳房切除术的患者，在了解为何该手术被认为对他们是最佳选择后，将能更好地应对。取消冰冻切片诊断将使患者摆脱当前乳腺癌治疗的一大恐惧——在不知道结果的情况下接受活检。这将使外科医生摆脱先进行冰冻切片然后进行乳房切除术的固定流程，并使他能够开始根据适当标准合理地将患者分配至保守治疗，而将乳房切除术保留给那些不符合这些标准的患者。
