外周给予P物质及其C末端序列pGlu6-SP6-11在大鼠中的强化作用。

Reinforcing effects of peripherally administered substance P and its C-terminal sequence pGlu6-SP6-11 in the rat.

作者信息

Oitzl M S, Hasenöhrl R U, Huston J P

机构信息

Institute of Physiological Psychology, University of Düsseldorf, Federal Republic of Germany.

出版信息

Psychopharmacology (Berl). 1990;100(3):308-15. doi: 10.1007/BF02244598.

DOI:10.1007/BF02244598

PMID:1690433

Abstract

Reinforcing effects of intraperitoneally (IP) administered substance P (SP1-11), its amino-terminal fragment SP1-7 (SPN) and an analog of the carboxy terminus (pGlu6-SP6-11: SPC) were studied in rats. Two conditioned place preference paradigms were used. After three pairings of the drug with a certain environment the effect of the treatment was evaluated in the drug-free state during a test trial. The reinforcing effects of SP (37 nmol) and the equimolar dose of SPC were expressed by a significant increase in the amount of time the animals spent in the treatment environment. Other doses of SP (3.7 and 185 nmol) and SPC (7.4 and 185 nmol) and none of the doses of SPN (37, 185, 370 nmol) influenced the place preference behavior of the rats. The reinforcing effects of SP parallel the known facilitating effects of peripherally administered SP on memory. The amino acids that encode the reinforcing effects of SP may lie within the C-terminal sequence of the SP molecule.

摘要

研究了腹腔注射P物质（SP1-11）、其氨基末端片段SP1-7（SPN）和羧基末端类似物（pGlu6-SP6-11：SPC）对大鼠的强化作用。使用了两种条件性位置偏爱范式。在将药物与特定环境进行三次配对后，在无药物状态下的测试试验中评估治疗效果。SP（37 nmol）和等摩尔剂量的SPC的强化作用表现为动物在治疗环境中停留时间显著增加。其他剂量的SP（3.7和185 nmol）和SPC（7.4和185 nmol）以及所有剂量的SPN（37、185、370 nmol）均未影响大鼠的位置偏爱行为。SP的强化作用与外周给予SP对记忆的已知促进作用相似。编码SP强化作用的氨基酸可能位于SP分子的C末端序列内。