Kostopoulos G, Gotman J
Electroencephalogr Clin Neurophysiol. 1984 Jan;57(1):69-82. doi: 10.1016/0013-4694(84)90009-9.
Two mutually complementary computer methods are described which can be used for the study of unit-EEG relationships during spontaneous EEG waves. The first one consists of using the unit activity to trigger the averaging of sections of EEG preceding and following each unit; the same unit activity is used for building a histogram of unit firing from another cell. Sections of data subjected to this analysis need not be continuous; they may be chosen interactively on the computer terminal, thus allowing to analyze intermittent phenomena. The second method consists of using a particular point of an EEG wave to trigger EEG averages from other channels as well as unit histograms. Here again the waves are chosen interactively. The unit-triggered EEG averages are more objective and less time consuming. However, they do not describe accurately the characteristics of the individual wave to which a unit firing is associated and also they give no information about inhibitory phenomena. Both these drawbacks are corrected by the wave-triggered unit histograms where the experimenter interactively selects and stores for analysis EEG waves with the appropriate characteristics. Several examples are given from the utilization of these programs in neurophysiological and neuropharmacological experiments, with special emphasis on generalized epilepsy.
本文描述了两种相互补充的计算机方法，可用于研究自发脑电活动期间单位脑电的关系。第一种方法是利用单位活动触发每个单位前后脑电部分的平均；同一单位活动用于构建另一个细胞的单位放电直方图。进行此分析的数据部分不必连续；可以在计算机终端上交互式选择，从而能够分析间歇性现象。第二种方法是利用脑电波的特定点触发其他通道的脑电平均以及单位直方图。同样，这些波也是交互式选择的。单位触发的脑电平均更客观且耗时更少。然而，它们不能准确描述与单位放电相关的单个波的特征，并且也没有提供关于抑制现象的信息。通过波触发的单位直方图可以纠正这两个缺点，实验者可以在其中交互式选择并存储具有适当特征的脑电波用于分析。文中给出了这些程序在神经生理学和神经药理学实验中的几个应用实例，特别强调了全身性癫痫。
