Wray D V, Hablitz J J
Brain Res. 1978 Oct 13;154(2):317-29. doi: 10.1016/0006-8993(78)90703-5.
Statistical analysis techniques that permit detection and quantification of EEG-single unit correlations were employed in a study of generalized penicillin epilepsy in the cat. Single unit activity was recorded in cerebral and cerebellar cortices and compared to the locally recorded EEG. It was found that during generalized paroxysmal activity the background EEG was significantly related to the time of occurrence of unit discharge. The degree of synchrony of various units differed but tended to increase as the duration and extent of paroxysmal activity increased. These relationships were usually not evident upon visual inspection of the original unprocessed data but were consistently detected by the analysis techniques described here. The results demonstrate the usefulness of a statistical approach to the analysis of single unit data and suggest that, not only is there a significant relationship between paroxysmal events and neuronal activity in generalized penicillin epilepsy, but also an overall trend to closer synchronization of EEG and single unit discharges during nonparoxysmal periods.
在一项关于猫的全身性青霉素癫痫的研究中，采用了能够检测和量化脑电图与单个神经元相关性的统计分析技术。在大脑和小脑皮质记录单个神经元活动，并与局部记录的脑电图进行比较。研究发现，在全身性阵发活动期间，背景脑电图与神经元放电发生时间显著相关。不同神经元的同步程度各不相同，但随着阵发活动的持续时间和范围增加，同步程度往往会上升。这些关系在对原始未处理数据进行目视检查时通常并不明显，但通过此处描述的分析技术能够持续检测到。结果证明了统计方法在分析单个神经元数据方面的有用性，并表明，在全身性青霉素癫痫中，不仅阵发事件与神经元活动之间存在显著关系，而且在非阵发期脑电图和单个神经元放电之间也存在总体上更紧密同步的趋势。
