Haro I, Torres J L, Valencia G, García-Antón J M, Reig F
Laboratory of Peptides, Centre for Research and Development (C.S.I.C.), Barcelona, Spain.
Int J Pept Protein Res. 1989 May;33(5):335-9. doi: 10.1111/j.1399-3011.1989.tb00690.x.
The synthesis of the hexapeptide [Glu6]SP6-11 and its glycosylated analogue at the Glu6 gamma-carboxyl position by solution procedures according to several strategies is discussed. The biological activity of SP, [Glu6]SP6-11 (VI) and [Glu(beta-D-Glcp)6]SP6-11 (VIII) have been determined and compared to SP by the GPI and RVD assays. The introduction of a beta-D-glucopyranosyl moiety at the sixth position of the [Glu6]SP6-11 did not affect to a great extent the in vitro activity pattern of the parent hexapeptide.
