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Analysis of cytidine deaminase and tetrahydrouridine interaction by use of ligand techniques.

作者信息

Stoller R G, Myers C E, Chabner B A

出版信息

Biochem Pharmacol. 1978 Jan 1;27(1):53-9. doi: 10.1016/0006-2952(78)90256-3.

DOI:10.1016/0006-2952(78)90256-3
PMID:619907
Abstract
摘要

相似文献

1
Analysis of cytidine deaminase and tetrahydrouridine interaction by use of ligand techniques.
Biochem Pharmacol. 1978 Jan 1;27(1):53-9. doi: 10.1016/0006-2952(78)90256-3.
2
On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase.
Biochemistry. 1975 Nov 18;14(23):5099-105. doi: 10.1021/bi00694a012.
3
Deoxycytidine transport in the presence of a cytidine deaminase inhibitor and the transport of uracil in Escherichia coli B.在胞苷脱氨酶抑制剂存在的情况下脱氧胞苷的转运以及尿嘧啶在大肠杆菌B中的转运。
J Biol Chem. 1975 May 25;250(10):3666-71.
4
Reduction of ara-C cytotoxicity in HL 60 cells by addition of deoxycytidine, cytidine or increased level of cytidine deaminase.通过添加脱氧胞苷、胞苷或提高胞苷脱氨酶水平来降低阿糖胞苷对HL 60细胞的细胞毒性。
Adv Exp Med Biol. 1989;253B:335-9. doi: 10.1007/978-1-4684-5676-9_49.
5
The action of bacterial cytidine deaminase on 5,6-dihydrocytidine.
Biochemistry. 1975 Feb 11;14(3):621-4. doi: 10.1021/bi00674a024.
6
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.使用5-三氟甲基脱氧胞苷和四氢尿苷来规避分解代谢，并利用肿瘤中高水平的胞苷脱氨酶实现DNA靶向和靶点导向治疗。
Cancer Res. 1985 Nov;45(11 Pt 1):5270-80.
7
Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside.人肝脏胞苷脱氨酶对5-氮杂-2'-脱氧胞苷和阿糖胞苷的脱氨动力学及其受3-脱氮尿苷、胸苷或阿糖尿苷的抑制作用。
Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9.
8
Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.
J Biol Chem. 1984 Nov 10;259(21):13621-7.
9
Kinetics and substrate specificity of human and canine cytidine deaminase.人和犬胞苷脱氨酶的动力学及底物特异性
Biochem Pharmacol. 1986 Apr 1;35(7):1199-201. doi: 10.1016/0006-2952(86)90160-7.
10
Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides.
J Med Chem. 1986 Nov;29(11):2351-8. doi: 10.1021/jm00161a034.

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MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism.MUC1 癌蛋白通过 CDA 介导的嘧啶代谢重编程减轻 ER 应激。
Oncogene. 2020 Apr;39(16):3381-3395. doi: 10.1038/s41388-020-1225-4. Epub 2020 Feb 26.
2
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.Tau蛋白在维持核糖体DNA稳定性和胞苷脱氨酶缺陷型细胞存活中的作用。
Nat Commun. 2017 Sep 25;8(1):693. doi: 10.1038/s41467-017-00633-1.
3
Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells.
扎布瑞林通过抑制 HepG2 细胞中的 DNMT1 和 PKR 而上调 CYP 基因的表达。
Sci Rep. 2017 Jan 23;7:41093. doi: 10.1038/srep41093.
4
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.胞苷脱氨酶缺乏诱导的嘧啶池失衡抑制PARP-1活性，导致DNA复制不足。
PLoS Genet. 2015 Jul 16;11(7):e1005384. doi: 10.1371/journal.pgen.1005384. eCollection 2015 Jul.
5
Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.四氢尿苷通过细胞周期调控抑制细胞增殖，而与胞苷脱氨酶表达水平无关。
PLoS One. 2012;7(5):e37424. doi: 10.1371/journal.pone.0037424. Epub 2012 May 16.
6
Stability of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in combination.5-氟-2'-脱氧胞苷和四氢尿苷联合的稳定性。
AAPS PharmSciTech. 2010 Mar;11(1):247-52. doi: 10.1208/s12249-010-9383-2. Epub 2010 Feb 12.
7
Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.胞苷脱氨酶抑制剂3,4,5,6-四氢尿苷在小鼠体内的血浆药代动力学及口服生物利用度
Cancer Chemother Pharmacol. 2008 Aug;62(3):457-64. doi: 10.1007/s00280-007-0625-2. Epub 2007 Nov 15.
8
Cytosine arabinoside triphosphate production in human leukaemic myeloblasts: interactions with deoxycytidine.人白血病成髓细胞中三磷酸阿糖胞苷的产生：与脱氧胞苷的相互作用
Cancer Chemother Pharmacol. 1981;5(3):185-92. doi: 10.1007/BF00258478.
9
Clinical management of cytotoxic drug overdose.细胞毒性药物过量的临床管理。
Med Toxicol Adverse Drug Exp. 1988 Jul-Aug;3(4):253-63. doi: 10.1007/BF03259938.
10
Pharmacokinetic drug interactions of commonly used anticancer drugs.常用抗癌药物的药代动力学药物相互作用。
Clin Pharmacokinet. 1986 May-Jun;11(3):223-35. doi: 10.2165/00003088-198611030-00004.