Villalobos Cuevas E, Soto Oviedo F, Arnaiz Toledo C, Bonavides Mateos C, Flores Pérez M, Figueroa Tarango A
Bol Med Hosp Infant Mex. 1978 Jan-Feb;35(1):189-96.
During the year 1976, 18 patients intoxicated with lomotil were admitted to the Emergency Service of the Centro Medico La Raza, I.M.S.S. with ages fluctuating between 4 months and 3 years; the average age was 22 mos. 88.8% of intoxications were accidental. Initial manifestations of atropinism and diphenoxylate showed the same proportion and 22% showed mixed symptoms. There were no deaths. All patients were given stomach washings and it was seen that the earlier the washing was given, the lesser the symptoms showed. The specific treatment given was with naloxone chloride (Narcanti) at a dose of 10 micrograms, per kilo and per dose intravenously and was repeated as often as necessary. Response was spectacular with improvement within 15 seconds. No patient showed side-effects to the application of the antagonist. Lomotil intoxication rated up to 15% of the total sum of intoxications admitted.
1976年期间，18名服用洛哌丁胺中毒的患者被送往墨西哥社会保障局拉萨医院医疗中心急诊室，年龄在4个月至3岁之间；平均年龄为22个月。88.8%的中毒为意外中毒。阿托品中毒和地芬诺酯中毒的初始表现比例相同，22%表现为混合症状。无死亡病例。所有患者均接受洗胃，发现洗胃越早，症状表现越轻。给予的特效治疗药物为氯 naloxone（纳康蒂），剂量为每公斤10微克，每次静脉注射，必要时可重复使用。反应显著，15秒内症状改善。没有患者因使用拮抗剂而出现副作用。洛哌丁胺中毒病例占所收治中毒病例总数的15%。
