Jiménez Rentería E, Garza Villarreal G, Porcayo Vergara F A, Serafín F J
Bol Med Hosp Infant Mex. 1977 Mar-Apr;34(2):519-26.
The authors reviewed the clinical histories of 50 children admitted to the Emergency Department of Hospital de Pediatría, C.M.N., I.M.S.S. from 1971 through 1975, with the diagnosis of lomotil intoxication. No differences were found as to sex. Frequency was greater at ages from 2 to 3 years from accidental mechanism, which increased between 1973 to 1975. Lethality was similar to that reported by other authors. In the clinical picture, the depressive action of diphenoxylate and the anticholinergic action of atropine were outstanding, without being possible to establish the limits between the two, with somnolence and flushness as main symptoms. The treatment given followed the purpose to eliminate the toxic: emesis, gastric washing and in cases of respiratory depression, naloxone was given. Therefore, it is concluded that since the value of lomotil in the treatment of diarrhea has not been proved and that the risk of its administration is greater than the benefit, this product should be proscribed, specially for pediatric use.
作者回顾了1971年至1975年期间入住墨西哥社会保障局儿童医学中心儿科急诊科、诊断为洛哌丁胺中毒的50名儿童的临床病史。在性别方面未发现差异。2至3岁儿童因意外接触导致的中毒频率更高，在1973年至1975年期间有所增加。致死率与其他作者报告的相似。在临床表现中，地芬诺酯的抑制作用和阿托品的抗胆碱能作用较为突出，无法区分两者的界限，主要症状为嗜睡和脸红。所采取的治疗旨在清除毒素：催吐、洗胃，对于呼吸抑制的病例，给予纳洛酮。因此，得出结论，由于洛哌丁胺在治疗腹泻方面的价值尚未得到证实，且其用药风险大于益处，该产品应被禁用，特别是儿科用药。
