一种控释罂粟碱片剂（帕帕康廷）：在正常志愿者中的一项研究。
A controlled release papaverine tablet (Papacontin): a study in normal volunteers.
作者信息
Miller R B, Leslie S T, Black F M, Boroda C
出版信息
Br J Clin Pharmacol. 1978 Jan;5(1):51-4. doi: 10.1111/j.1365-2125.1978.tb01597.x.
Abstract
- A controlled release tablet containing 300 mg of papaverine hydrochloride was compared with a capsule containing the same dose. 2. The in vitro release pattern showed a steady dissolution of the tablet, with release of the papaverine over 10 h, whereas the capsule release time was 40 min. 3. Plasma levels in volunteers who were given the tablet showed a rapid rise to therapeutic levels (150-300 ng/ml) within 1 h, and maintenance of these levels for 10-12 h, with no accumulation on repeated 12 hourly dosage. Administration of the capsule produced early peaking and a subsequent rapid fall in plasma levels.
摘要
- 将含有300毫克盐酸罂粟碱的控释片与含有相同剂量的胶囊进行比较。2. 体外释放模式显示该片剂溶解稳定，罂粟碱在10小时内释放，而胶囊的释放时间为40分钟。3. 服用该片剂的志愿者血浆水平在1小时内迅速升至治疗水平（150 - 300纳克/毫升），并在10 - 12小时内维持这些水平，每12小时重复给药无蓄积现象。服用胶囊后血浆水平早期达到峰值，随后迅速下降。
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J Pharmacol Exp Ther. 1958 Sep;124(1):9-15.
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Comparison of the bioavailability of aminophylline in a conventional base and in a continous-release base.氨茶碱在传统剂型和缓释剂型中的生物利用度比较。
J Clin Pharmacol. 1973 Oct;13(10):383-7. doi: 10.1002/j.1552-4604.1973.tb00183.x.
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