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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Miller R B, Leslie S T, Black F M, Boroda C

Br J Clin Pharmacol. 1978 Jan;5(1):51-4. doi: 10.1111/j.1365-2125.1978.tb01597.x.

A controlled release tablet containing 300 mg of papaverine hydrochloride was compared with a capsule containing the same dose. 2. The in vitro release pattern showed a steady dissolution of the tablet, with release of the papaverine over 10 h, whereas the capsule release time was 40 min. 3. Plasma levels in volunteers who were given the tablet showed a rapid rise to therapeutic levels (150-300 ng/ml) within 1 h, and maintenance of these levels for 10-12 h, with no accumulation on repeated 12 hourly dosage. Administration of the capsule produced early peaking and a subsequent rapid fall in plasma levels.

将含有300毫克盐酸罂粟碱的控释片与含有相同剂量的胶囊进行比较。2. 体外释放模式显示该片剂溶解稳定，罂粟碱在10小时内释放，而胶囊的释放时间为40分钟。3. 服用该片剂的志愿者血浆水平在1小时内迅速升至治疗水平（150 - 300纳克/毫升），并在10 - 12小时内维持这些水平，每12小时重复给药无蓄积现象。服用胶囊后血浆水平早期达到峰值，随后迅速下降。

Miller R B, Leslie S T, Black F M, Boroda C

Br J Clin Pharmacol. 1978 Jan;5(1):51-4. doi: 10.1111/j.1365-2125.1978.tb01597.x.

A controlled release tablet containing 300 mg of papaverine hydrochloride was compared with a capsule containing the same dose. 2. The in vitro release pattern showed a steady dissolution of the tablet, with release of the papaverine over 10 h, whereas the capsule release time was 40 min. 3. Plasma levels in volunteers who were given the tablet showed a rapid rise to therapeutic levels (150-300 ng/ml) within 1 h, and maintenance of these levels for 10-12 h, with no accumulation on repeated 12 hourly dosage. Administration of the capsule produced early peaking and a subsequent rapid fall in plasma levels.

将含有300毫克盐酸罂粟碱的控释片与含有相同剂量的胶囊进行比较。2. 体外释放模式显示该片剂溶解稳定，罂粟碱在10小时内释放，而胶囊的释放时间为40分钟。3. 服用该片剂的志愿者血浆水平在1小时内迅速升至治疗水平（150 - 300纳克/毫升），并在10 - 12小时内维持这些水平，每12小时重复给药无蓄积现象。服用胶囊后血浆水平早期达到峰值，随后迅速下降。