Lee B Y, Sakamoto H, Trainor F, Brody G, Cho Y W
Int J Clin Pharmacol Biopharm. 1978 Jan;16(1):32-9.
The vasodilatory action, plasma papaverine levels achieved, and the incidence of side effects after oral administration of papaverine hydrochloride as a soft gelatin capsule, were compared to those of a sustained release formulation. The incidence of side effects observed after 150 mg, two or three times per day, of the soft gelatin capsule was similar to that observed after 150 mg, twice per day, of the sustained release form in 15 patients with arteriosclerosis obliterans. A relatively higher plasma papaverine concentration was achieved, 120 minutes after 150 mg administration of the soft gelatin form, compared to an equivalent dose of the sustained release form. The degree of vasodilation obtained after four doses (150 mg X 4) of soft gelatin within 24 hrs., was significantly superior than that induced after four doses (150 mg X 4) of the sustained release form in 6 patients with a severe degree of arteriosclerosis obliterans.
将盐酸罂粟碱制成软胶囊口服后的血管舒张作用、血浆罂粟碱水平以及副作用发生率，与缓释制剂进行了比较。在15例闭塞性动脉硬化患者中，每天服用2或3次150mg软胶囊后观察到的副作用发生率，与每天服用2次150mg缓释制剂后观察到的相似。与同等剂量的缓释制剂相比，服用150mg软胶囊后120分钟，血浆罂粟碱浓度相对较高。在6例重度闭塞性动脉硬化患者中，24小时内服用4剂（150mg×4）软胶囊后获得的血管舒张程度，明显优于服用4剂（150mg×4）缓释制剂后诱导的血管舒张程度。
