Ghazizadeh M, Kagawa S, Izumi K, Maebayashi K, Takigawa H, Saiki T, Kawano A, Kurokawa K
J Urol. 1984 Mar;131(3):501-3. doi: 10.1016/s0022-5347(17)50466-8.
Immunoperoxidase localization of carcinoembryonic antigen was done on tissue sections of benign hyperplasia and adenocarcinoma of the prostate using murine monoclonal antibody against carcinoembryonic antigen. The study was done to determine whether carcinoembryonic antigen would be a tissue marker of prostatic malignancy. Of 30 benign lesions 25 (83 per cent) were negative and 5 had focally weak staining, while of 36 adenocarcinomas 31 (86 per cent) had diffusely positive staining and 5 were negative. Diffusely moderate or strong staining was noted in 5 of 10 grade I (50 per cent), 11 of 12 (92 per cent) grade II and 13 of 14 (93 per cent) grade III tumors, as well as 14 of 15 (93 per cent) tumors from patients with bone metastasis. These findings suggested that extensive immunostaining for carcinoembryonic antigen in prostatic glandular lesions might be a potentially important prognostic marker of malignancy. Further studies are warranted to extend and confirm these results.
使用抗癌胚抗原的鼠单克隆抗体，对前列腺良性增生和腺癌的组织切片进行癌胚抗原的免疫过氧化物酶定位。进行该研究以确定癌胚抗原是否会成为前列腺恶性肿瘤的组织标志物。在30个良性病变中，25个（83%）为阴性，5个有局灶性弱阳性染色；而在36个腺癌中，31个（86%）有弥漫性阳性染色，5个为阴性。在10个I级肿瘤中的5个（50%）、12个II级肿瘤中的11个（92%）、14个III级肿瘤中的13个（93%）以及15个有骨转移患者的肿瘤中的14个（93%）观察到弥漫性中度或强染色。这些发现表明，前列腺腺性病变中癌胚抗原的广泛免疫染色可能是恶性肿瘤潜在的重要预后标志物。有必要进行进一步研究以扩展和证实这些结果。
