血管活性肽和化合物48/80刺激肥大细胞后内源性5-羟色胺和组胺的平行分泌
Parallel secretion of endogenous 5-hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80.
作者信息
Carraway R E, Cochrane D E, Granier C, Kitabgi P, Leeman E, Singer E A
出版信息
Br J Pharmacol. 1984 Feb;81(2):227-9. doi: 10.1111/j.1476-5381.1984.tb10069.x.
Abstract
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5-HT.
摘要
肽类物质神经降压素、P物质、生长抑素和蛙皮素、神经降压素的几种类似物和片段以及化合物48/80，均能引起内源性5-羟色胺（5-HT）和组胺的分泌。所测试的任何一种促分泌剂对5-HT和组胺的分泌均无差异影响。阿米替林可抑制神经降压素、P物质、生长抑素或化合物48/80刺激引起的组胺分泌，但对内源性5-HT的分泌没有影响。
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