Berlin G, Enerbäck L
Agents Actions. 1986 Apr;18(1-2):89-91. doi: 10.1007/BF01987991.
A differential amine release from mast cells induced by an inhibitory effect of the antidepressant drug amitriptyline on the release of histamine but not on that of serotonin has recently been reported. In view of the potential biological importance of a differential release of mast cell amines we have studied the effect of amitriptyline on the dynamics of the secretory process using a combination of vital berberine staining (demonstrating intracellular granules that have released amines) and measurement of histamine, serotonin (5-HT), and heparin release. The results show a non-differential inhibition of the release of histamine and 5-HT by amitriptyline. The basic pattern of the secretory process, studied in terms of granule extrusion and amine release from intracellular granules, was unaffected by the drug.
最近有报道称，抗抑郁药物阿米替林对组胺释放具有抑制作用，但对血清素释放无抑制作用，由此诱导肥大细胞产生不同的胺释放。鉴于肥大细胞胺的差异释放具有潜在的生物学重要性，我们结合使用活性黄连素染色（显示已释放胺的细胞内颗粒）以及组胺、血清素（5-HT）和肝素释放的测量，研究了阿米替林对分泌过程动力学的影响。结果显示，阿米替林对组胺和5-HT的释放具有非差异性抑制作用。从颗粒挤出和细胞内颗粒胺释放方面研究的分泌过程基本模式不受该药物影响。
