Bloch R S, Weaver D W, Bouwman D L, Berger G
J Surg Res. 1984 Apr;36(4):389-94. doi: 10.1016/0022-4804(84)90116-1.
The effects of alcohol intoxication on serum amylase levels were tested in both normal subjects and chronic alcoholics. Paired samples of ethanol levels and isoamylase levels in the normal subjects (n = 11) showed a rise in both total serum amylase (P less than 0.01) and nonpancreatic isoamylase (P less than 0.05) after drinking. Unpaired cohort groups of sober chronic alcoholics at a rehabilitation facility (n = 46) and intoxicated chronic alcoholics in an emergency room (n = 58) were also compared. Average blood alcohol levels in the intoxicated controls were 93 mg% compared to a level of 301 mg% in the intoxicated chronic alcoholic. Intoxication superimposed on chronic alcoholism caused a moderate rise in the total serum amylase (NS) and a significant elevation of the nonpancreatic isoamylase (P less than 0.01). Sober chronic alcoholics had a significantly greater average total serum amylase (P less than 0.001) and nonpancreatic isoamylase (P less than 0.01) than the normal controls. No difference in the average pancreatic isoamylase levels was seen in any group. These data suggest a biphasic response to alcohol on the serum amylase level. Acute and chronic changes appear to operate independently. The cause for these effects is speculative. Isoamylase analysis is needed in the alcoholic population to sort out the meaning of hyperamylasemia.
在正常受试者和慢性酒精中毒者中测试了酒精中毒对血清淀粉酶水平的影响。正常受试者（n = 11）的乙醇水平和异淀粉酶水平配对样本显示，饮酒后血清总淀粉酶（P < 0.01）和非胰腺异淀粉酶（P < 0.05）均升高。还比较了康复机构中清醒的慢性酒精中毒者（n = 46）和急诊室中醉酒的慢性酒精中毒者（n = 58）的非配对队列组。醉酒对照组的平均血酒精水平为93mg%，而醉酒慢性酒精中毒者的水平为301mg%。慢性酒精中毒叠加醉酒导致血清总淀粉酶适度升高（无统计学意义），非胰腺异淀粉酶显著升高（P < 0.01）。清醒的慢性酒精中毒者的平均血清总淀粉酶（P < 0.001）和非胰腺异淀粉酶（P < 0.01）明显高于正常对照组。任何组的平均胰腺异淀粉酶水平均无差异。这些数据表明血清淀粉酶水平对酒精有双相反应。急性和慢性变化似乎独立起作用。这些影响的原因是推测性的。需要对酒精中毒人群进行异淀粉酶分析以理清高淀粉酶血症的意义。
