Murray N, Steck A J
Lancet. 1984 Mar 31;1(8379):711-3. doi: 10.1016/s0140-6736(84)92224-4.
In three patients with monoclonal IgM antibodies to myelin-associated glycoprotein and a demyelinating neuropathy, the human monoclonal antibodies and HNK1, a mouse monoclonal antibody against human natural killer cells, reacted with the same region of myelin-associated glycoprotein. In these three patients there was a pronounced decrease in the number of circulating HNK1-positive cells. Taken together, these findings provide evidence that a cross-reactive cell surface antigen may be involved in an autoimmune response directed simultaneously against the nervous system and the immune system.
在三名患有针对髓鞘相关糖蛋白的单克隆IgM抗体和脱髓鞘性神经病的患者中，人单克隆抗体和HNK1（一种针对人类自然杀伤细胞的小鼠单克隆抗体）与髓鞘相关糖蛋白的同一区域发生反应。在这三名患者中，循环中HNK1阳性细胞的数量明显减少。综上所述，这些发现提供了证据，表明一种交叉反应性细胞表面抗原可能参与了同时针对神经系统和免疫系统的自身免疫反应。
