Nawa H, Doteuchi M, Igano K, Inouye K, Nakanishi S
Life Sci. 1984 Mar 19;34(12):1153-60. doi: 10.1016/0024-3205(84)90087-0.
The primary structure of one of the bovine brain substance P precursors has shown the existence of a second mammalian tachykinin sequence, named substance K, that is remarkably homologous to that of the amphibian peptide kassinin. In this study, three substance K sequences were chemically synthesized and were submitted to parallel bioassays with kassinin, substance P and physalaemin. The results show that the three substance K peptides all possess biological activities characteristic of the tachykinin family and that their biological activities more closely resemble those of kassinin than those of substance P or physalaemin. This suggests that substance K may have a physiological role which is related to but different from that of substance P in mammalian organisms.
牛脑P物质前体之一的一级结构表明存在第二个哺乳动物速激肽序列,名为K物质,它与两栖类肽肛褶蛙肽的序列显著同源。在本研究中,化学合成了三个K物质序列,并与肛褶蛙肽、P物质和 Physalaemin进行了平行生物测定。结果表明,这三个K物质肽均具有速激肽家族的生物学活性特征,且它们的生物学活性与肛褶蛙肽的更为相似,而非与P物质或 Physalaemin的相似。这表明K物质在哺乳动物机体中可能具有与P物质相关但不同的生理作用。