Montgomery R R, Otsuka A, Hathaway W E
Blood. 1978 Feb;51(2):299-306.
A patient with a significant history of spontaneous and posttraumatic bleeding was found to have hypoprothrombinemia. His prothrombin (factor II) activity by clotting assay was 9.5% and his factor II antigen was 5%. Crossed immunoelectrophoresis and sucrose density gradient ultracentrifugation of the patient's plasma showed his prothrombin to be qualitatively indistinguishable from normal prothrombin by these techniques.
一名有明显自发和创伤后出血病史的患者被发现患有低凝血酶原血症。通过凝血测定，他的凝血酶原（因子II）活性为9.5%，因子II抗原为5%。对该患者血浆进行交叉免疫电泳和蔗糖密度梯度超速离心，结果显示，通过这些技术，他的凝血酶原在质量上与正常凝血酶原无法区分。
