Harrison R L, Alperin J B, Kumar D
Arch Pathol Lab Med. 1987 Aug;111(8):719-22.
A man with lupus anticoagulant and a prothrombin deficiency was studied before and after cessation of treatment with phenytoin. Multiple abnormal laboratory values of the following partially or completely resolved after the patient's therapy was discontinued: tissue thromboplastin inhibition ratio, prothrombin time, activated partial thromboplastin time, anticardiolipin antibodies, and quantitative measures and abnormal pattern on crossed immunoelectrophoresis of prothrombin. This patient represented an example of a concurrent drug-induced prothrombin deficiency and a lupus anticoagulant.
对一名患有狼疮抗凝物和凝血酶原缺乏症的男性患者在停用苯妥英治疗前后进行了研究。在患者停止治疗后，以下多项异常实验室检查值部分或完全恢复正常：组织凝血活酶抑制率、凝血酶原时间、活化部分凝血活酶时间、抗心磷脂抗体以及凝血酶原交叉免疫电泳的定量测定和异常图谱。该患者是药物诱导的凝血酶原缺乏症和狼疮抗凝物并存的一个例子。
