Linnestad P, Schrumpf E
Scand J Gastroenterol. 1983 May;18(3):385-9. doi: 10.3109/00365528309181611.
The pancreatic polypeptide (PP) release after a standard meal and the PP release and the pancreatic secretion of bicarbonate and amylase after stimulation by secretin GIH, 1 CU kg-1 intravenously, and by cholecystokinin (CCK), 1 Ivy dog unit kg-1 intravenously, have been investigated in 10 patients with chronic pancreatitis. Significant correlations were found between the integrated PP responses after food and hormonal stimulation (p less than 0.05), between the integrated PP response and the peak serum PP concentration after food (p less than 0.01) and after secretin/CCK (p less than 0.01), and between the peak serum PP concentrations obtained after food, secretin, and CCK (p less than 0.01). The pancreatic outputs of bicarbonate and amylase and the peak amylase concentration after hormonal stimulation were significantly correlated (p less than 0.01), but no significant correlation was found between any one of these variables of exocrine pancreatic function and the PP release. It is concluded that, in chronic pancreatitis, food, secretin, and CCK stimulate PP release similarly and that no correlation can be established between the PP release and the exocrine pancreatic secretion.
对10例慢性胰腺炎患者进行了研究，观察他们在进标准餐后的胰多肽（PP）释放情况，以及静脉注射1 CU/kg体重的胰泌素（GIH）和1 Ivy犬单位/kg体重的胆囊收缩素（CCK）刺激后PP的释放情况、胰腺碳酸氢盐和淀粉酶的分泌情况。发现进食后与激素刺激后的PP综合反应之间（p<0.05）、进食后PP综合反应与血清PP峰值浓度之间（p<0.01）、胰泌素/CCK刺激后PP综合反应与血清PP峰值浓度之间（p<0.01），以及进食、胰泌素和CCK刺激后获得的血清PP峰值浓度之间（p<0.01）均存在显著相关性。激素刺激后胰腺碳酸氢盐和淀粉酶的分泌量与淀粉酶峰值浓度显著相关（p<0.01），但外分泌胰腺功能的这些变量中的任何一个与PP释放之间均未发现显著相关性。得出结论，在慢性胰腺炎中，食物、胰泌素和CCK对PP释放的刺激作用相似，且PP释放与胰腺外分泌之间无法建立相关性。
