胰多肽抑制生长抑素分泌。
Pancreatic polypeptide inhibits somatostatin secretion.
作者信息
Kim Wook, Fiori Jennifer L, Shin Yu-Kyong, Okun Eitan, Kim Jung Seok, Rapp Peter R, Egan Josephine M
机构信息
Department of Molecular Science and Technology, Ajou University, Suwon 443-749, South Korea.
Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
FEBS Lett. 2014 Aug 25;588(17):3233-9. doi: 10.1016/j.febslet.2014.07.005. Epub 2014 Jul 11.
Abstract
Pancreatic polypeptide (PP) is a major agonist for neuropeptide Y4 receptors (NPY4R). While NPY4R has been identified in various tissues, the cells on which it is expressed and its function in those cells has not been clearly delineated. Here we report that NPY4R is present in all somatostatin-containing cells of tissues that we tested, including pancreatic islets, duodenum, hippocampus, and hypothalamus. Its agonism by PP decreases somatostatin secretion from human islets. Mouse embryonic hippocampal (mHippo E18) cells expressed NPY4Rs and their activation by PP consistently decreased somatostatin secretion. Furthermore, central injection of PP in mice induced c-Fos immunoreactivity in somatostatin-containing cells in the hippocampus compared with PBS-injected mice. In sum, our results identify PP as a pivotal modulator of somatostatin secretion.
摘要
胰多肽（PP）是神经肽Y4受体（NPY4R）的主要激动剂。虽然已在多种组织中鉴定出NPY4R，但其表达的细胞及其在这些细胞中的功能尚未明确界定。在此我们报告，在我们测试的组织中，包括胰岛、十二指肠、海马体和下丘脑，所有含生长抑素的细胞中均存在NPY4R。PP对其的激动作用可减少人胰岛中生长抑素的分泌。小鼠胚胎海马（mHippo E18）细胞表达NPY4R，PP对其激活可持续减少生长抑素的分泌。此外，与注射PBS的小鼠相比，向小鼠脑内注射PP可诱导海马体中含生长抑素细胞的c-Fos免疫反应性。总之，我们的结果表明PP是生长抑素分泌的关键调节因子。
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本文引用的文献
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Diabetes. 2013 Oct;62(10):3500-13. doi: 10.2337/db13-0266. Epub 2013 Jul 24.
2
Hilar interneuron vulnerability distinguishes aged rats with memory impairment.老化记忆损伤大鼠的 hilar 中间神经元易损性特征。
J Comp Neurol. 2013 Oct 15;521(15):3508-23. doi: 10.1002/cne.23367.
3
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Neuropeptides. 2012 Dec;46(6):261-74. doi: 10.1016/j.npep.2012.08.005. Epub 2012 Sep 11.
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Diabetologia. 2012 Nov;55(11):3094-103. doi: 10.1007/s00125-012-2663-5. Epub 2012 Aug 8.
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J Neurosci. 2010 Oct 13;30(41):13707-17. doi: 10.1523/JNEUROSCI.4040-10.2010.
6
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9
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10
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