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膳食糖促进成年大鼠肠道细胞染色质中的基因激活。

Dietary sugar promotes gene activation in intestinal cell chromatin of adult rats.

作者信息

Raul F, von der Decken A

出版信息

Experientia. 1984 Apr 15;40(4):364-5. doi: 10.1007/BF01952554.

DOI:10.1007/BF01952554
PMID:6201386
Abstract

The effect of dietary sucrose on transcription activity of chromatin from intestinal cells of adult rats was investigated. Chromatin-bound RNA polymerase II activity was significantly enhanced after feeding sucrose to rats. RNA polymerase II transcribes the genes coding for pre-messenger RNA. The results indicate that feeding of sucrose increased the synthesis of pre-messenger RNA molecules coding for specific proteins which are involved in the adaptive processes of sucrose hydrolysis in intestinal cells.

摘要

研究了日粮蔗糖对成年大鼠肠道细胞染色质转录活性的影响。给大鼠喂食蔗糖后,染色质结合的RNA聚合酶II活性显著增强。RNA聚合酶II转录编码前体信使RNA的基因。结果表明,喂食蔗糖增加了编码特定蛋白质的前体信使RNA分子的合成,这些蛋白质参与肠道细胞中蔗糖水解的适应性过程。

相似文献

1
Dietary sugar promotes gene activation in intestinal cell chromatin of adult rats.膳食糖促进成年大鼠肠道细胞染色质中的基因激活。
Experientia. 1984 Apr 15;40(4):364-5. doi: 10.1007/BF01952554.
2
Modulation of RNA polymerase activities in the intestine of adult rats by dietary sucrose.膳食蔗糖对成年大鼠肠道中RNA聚合酶活性的调节作用。
J Nutr. 1983 Oct;113(10):2034-40. doi: 10.1093/jn/113.10.2034.
3
Stimulation of intestinal chromatin template activity by dietary carbohydrates in adult rats.成年大鼠膳食碳水化合物对肠道染色质模板活性的刺激作用。
Experientia. 1983 Feb 15;39(2):166-7. doi: 10.1007/BF01958879.
4
Changes in chromatin structure and transcription activity by starvation and dietary sucrose in mature and immature intestinal epithelial cells of the rat.饥饿及膳食蔗糖对大鼠成熟和未成熟肠上皮细胞染色质结构及转录活性的影响
Cell Mol Biol. 1985;31(4):299-304.
5
Increased transcription activity of rat liver chromatin after protein restriction and limited digestion of nuclei with micrococcus nuclease.蛋白质限制及用微球菌核酸酶对细胞核进行有限消化后大鼠肝脏染色质转录活性增强。
J Nutr. 1981 Jul;111(7):1249-57. doi: 10.1093/jn/111.7.1249.
6
Reduced transcription activity of rat liver chromatin after protein restriction and selective digestion of nuclei with micrococcus nuclease.蛋白质限制及用微球菌核酸酶对细胞核进行选择性消化后大鼠肝脏染色质转录活性降低。
J Nutr. 1981 Jul;111(7):1258-64. doi: 10.1093/jn/111.7.1258.
7
Effect of sucrose diet on apolipoprotein biosynthesis in rat liver. Increase in apolipoprotein E gene transcription.蔗糖饮食对大鼠肝脏载脂蛋白生物合成的影响。载脂蛋白E基因转录增加。
J Biol Chem. 1989 Jan 15;264(2):1190-4.
8
Effect of dietary sucrose on synthesis and degradation of intestinal sucrase.膳食蔗糖对肠道蔗糖酶合成与降解的影响。
Am J Physiol. 1984 Jun;246(6 Pt 1):G757-63. doi: 10.1152/ajpgi.1984.246.6.G757.
9
Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum.饮食中的果糖可协同增强大鼠空肠中蔗糖酶-异麦芽糖酶和己糖转运蛋白的基因表达。
J Nutr. 1999 May;129(5):953-6. doi: 10.1093/jn/129.5.953.
10
Effect of in vitro (ADP)ribosylation on transcription of the chromatin of the brain of developing rats.体外(ADP)核糖基化对发育中大鼠大脑染色质转录的影响。
Mol Biol Rep. 1987;12(1):43-7. doi: 10.1007/BF00580649.

引用本文的文献

1
Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine.存在一种可能控制小鼠肠道蔗糖酶表达的调控基因(Suc-1)的证据。
Biochem Genet. 1986 Apr;24(3-4):169-81. doi: 10.1007/BF00502786.

本文引用的文献

1
Release of transcriptionally active chromatin from liver nuclei by micrococcus nuclease.用微球菌核酸酶从肝细胞核中释放转录活性染色质。
Life Sci. 1980 Mar 10;26(10):797-804. doi: 10.1016/0024-3205(80)90286-6.
2
Effect of a protein-free diet and fasting on RNA polymerase activity in mice.无蛋白饮食和禁食对小鼠RNA聚合酶活性的影响。
J Nutr. 1982 Feb;112(2):293-8. doi: 10.1093/jn/112.2.293.
3
Alteration of the structure and function of rat liver chromatin by nutritional factors.营养因素对大鼠肝脏染色质结构和功能的改变。
Nutr Rev. 1980 Jan;38(1):1-8. doi: 10.1111/j.1753-4887.1980.tb05823.x.
4
Sucrase-isomaltase regulation by dietary sucrose in the rat.大鼠中膳食蔗糖对蔗糖酶-异麦芽糖酶的调节作用。
Gastroenterology. 1983 Jan;84(1):18-25.
5
Effect of sucrose refeeding on disaccharidase and aminopeptidase activities of intestinal villus and crypt cells in adult rats. Evidence for a sucrose-dependent induction of sucrase in the crypt cells.蔗糖再喂养对成年大鼠肠绒毛和隐窝细胞双糖酶及氨肽酶活性的影响。隐窝细胞中蔗糖酶的蔗糖依赖性诱导的证据。
Biochim Biophys Acta. 1980 Jun 5;630(1):1-9. doi: 10.1016/0304-4165(80)90130-0.
6
Stimulation of intestinal chromatin template activity by dietary carbohydrates in adult rats.成年大鼠膳食碳水化合物对肠道染色质模板活性的刺激作用。
Experientia. 1983 Feb 15;39(2):166-7. doi: 10.1007/BF01958879.
7
[Is stimulation of intestinal sucrase activity by dietary sucrose dependent on RNA synthesis in adult rats? (author's transl)].成年大鼠中膳食蔗糖对肠蔗糖酶活性的刺激是否依赖于RNA合成?(作者译)
Gastroenterol Clin Biol. 1982 May;6(5):424-9.
8
High concentration of RNA polymerase I is responsible for the high rate of nucleolar transcription.高浓度的RNA聚合酶I是核仁高转录率的原因。
Biochem J. 1980 May 15;188(2):381-5. doi: 10.1042/bj1880381.
9
Two functional states of the RNA polymerases in the rat hepatic nuclear and nucleolar fractions.大鼠肝细胞核和核仁组分中RNA聚合酶的两种功能状态。
Nature. 1974 Sep 27;251(5473):344-6. doi: 10.1038/251344a0.
10
Stimulation of transcription of mouse kidney chromatin by sulfated polysaccharides.硫酸化多糖对小鼠肾脏染色质转录的刺激作用。
Nucleic Acids Res. 1975 May;2(5):735-44. doi: 10.1093/nar/2.5.735.