Weinstein I B, Gattoni-Celli S, Kirschmeier P, Hsiao W, Horowitz A, Jeffrey A
Fed Proc. 1984 May 15;43(8):2287-94.
Recent studies indicate that although cellular DNA is the critical target in the action of initiating carcinogens, specific membrane-associated receptors mediate the actions of certain tumor promoters. A stereochemical model is presented to explain how three different types of tumor promoters (phorbol esters, indole alkaloids, and polyacetates) can interact with the same class of cellular receptors. Multistage chemical carcinogenesis might involve progressive alterations in the expression of cellular DNA sequences homologous to oncogenes and regulatory sequences in certain retroviruses. We found that the oncogene c-mos is not rearranged or expressed in a series of carcinogen-transformed murine C3H 10T112 cells. These cells do express, however, a unique set of poly(A)+ RNAs that contain sequences homologous to the Moloney leukemia virus long terminal repeat sequence. Studies are in progress to determine the significance of this finding with respect to the carcinogenic process.
最近的研究表明，虽然细胞DNA是引发致癌物作用的关键靶点，但特定的膜相关受体介导某些肿瘤促进剂的作用。本文提出了一个立体化学模型，以解释三种不同类型的肿瘤促进剂（佛波酯、吲哚生物碱和聚醋酸酯）如何与同一类细胞受体相互作用。多阶段化学致癌作用可能涉及与某些逆转录病毒中的癌基因和调控序列同源的细胞DNA序列表达的渐进性改变。我们发现，癌基因c-mos在一系列致癌物转化的小鼠C3H 10T1/2细胞中未发生重排或表达。然而，这些细胞确实表达了一组独特的多聚腺苷酸加尾RNA，其包含与莫洛尼白血病病毒长末端重复序列同源的序列。目前正在进行研究，以确定这一发现对致癌过程的意义。
