De Simone C, Delogu G, Pugnaloni L, Mastropietro C
Int J Tissue React. 1984;6(1):101-4.
Methisoprinol is an antiviral drug with immunopotentiating properties. The aim of this study was to assess the immunopharmacokinetic profile of the drug alone or administered in conjunction with corticosteroids. The plasma of patients who had been given a single dose of methisoprinol, prednisolone or both was collected before the infusion and at different time intervals thereafter. The plasma samples were tested for immunosuppressive or immunopotentiating activity in a mixed lymphocyte culture (MLC). The test was modified to increase sensitivity and decrease variability. The administration of methisoprinol resulted in increased responses up to three hours after the infusion. The simultaneous administration of both drugs resulted in an even more marked inhibition of MLCs as compared with corticosteroids alone.
美替沙腙是一种具有免疫增强特性的抗病毒药物。本研究的目的是评估该药物单独使用或与皮质类固醇联合使用时的免疫药代动力学特征。在输注前及输注后的不同时间间隔，收集接受单剂量美替沙腙、泼尼松龙或两者的患者的血浆。在混合淋巴细胞培养（MLC）中检测血浆样本的免疫抑制或免疫增强活性。对该试验进行了改进，以提高敏感性并降低变异性。输注美替沙腙后三小时内，反应增强。与单独使用皮质类固醇相比，两种药物同时使用对混合淋巴细胞培养的抑制作用更为明显。
