Mentnech M S, Lewis D M, Olenchock S A, Mull J C, Koller W A, Lewis T R
J Toxicol Environ Health. 1984;13(1):31-41. doi: 10.1080/15287398409530479.
The effects on the immune system of rats that had been exposed to a 2-mg/m3 dose of either respirable coal dust, diesel exhaust fumes and particulates, or the combination of these were studied. Animals that were housed similarly but exposed only to filtered air served as controls. After 12 and 24 mo of exposure, the rats were tested for immunocompetency by enumerating antibody-producing cells in the spleen 4 d after immunization with sheep erythrocytes and by monitoring the proliferative response of splenic T-lymphocytes to the mitogens concanavalin A and phytohemagglutinin. The results of this study indicate that no major alterations occurred in the immunologic functions measured as a result of exposure to either coal dust, diesel exhaust fumes and particulates, or their combination.
研究了暴露于2毫克/立方米可吸入煤尘、柴油废气和颗粒物或它们的组合剂量下的大鼠免疫系统的影响。将饲养条件相同但仅暴露于过滤空气中的动物作为对照。在暴露12个月和24个月后，通过在用绵羊红细胞免疫4天后计数脾脏中产生抗体的细胞以及监测脾T淋巴细胞对有丝分裂原刀豆球蛋白A和植物血凝素的增殖反应来检测大鼠的免疫能力。这项研究的结果表明，暴露于煤尘、柴油废气和颗粒物或它们的组合后，所测量的免疫功能没有发生重大改变。
