Kawaura Y, Kaneko Y, Iwa T
Nihon Geka Gakkai Zasshi. 1983 Jan;84(1):74-9.
Twenty dogs were divided into four groups. Group A; IVH without Fat emulsion was performed transvenously. Group B: IVH with Fat emulsion transvenously. Group C; IVH without Fat emulsion transportally. Group D: IVH with Fat emulsion transportally. Infusion dose was for 24 hours. The results were as follows: 1) Blood sugar and I.R.L.: In group B and D, both blood sugar and I.R.I. reached the peak at the 24th hour. However, in the 1st week, they became normal value. In group D, Blood sugar was higher than that in group B, but I.R.I. value was lower. 2) Free fatty acid (FFA): in group A and C, FFA were gradually increased, but in group B and D, they reached the preoperative value in the 1st week. In group D, it was lower than that in group B. 3) Histological findings of the liver: in group A-D, lobular necrosis and fat degeneration were seen. In this study, we emphasized that transportal hyperalimentation with fat emulsion as the treatment of acute pancreatitis was physiologically effective especially in control of blood sugar and inhibition of lipolysis.
将20只狗分为四组。A组：经静脉进行无脂肪乳剂的静脉内高营养。B组：经静脉进行含脂肪乳剂的静脉内高营养。C组：经门静脉进行无脂肪乳剂的门静脉内高营养。D组：经门静脉进行含脂肪乳剂的门静脉内高营养。输注剂量为24小时。结果如下：1）血糖和胰岛素释放指数：在B组和D组中，血糖和胰岛素释放指数均在第24小时达到峰值。然而，在第1周时，它们恢复到正常值。在D组中，血糖高于B组，但胰岛素释放指数值较低。2）游离脂肪酸（FFA）：在A组和C组中，游离脂肪酸逐渐升高，但在B组和D组中，它们在第1周时恢复到术前值。在D组中，其低于B组。3）肝脏组织学检查结果：在A - D组中，可见小叶坏死和脂肪变性。在本研究中，我们强调以脂肪乳剂进行门静脉内高营养作为急性胰腺炎的治疗方法在生理上是有效的，特别是在控制血糖和抑制脂肪分解方面。
