鸟氨酸氨甲酰基转移酶在肝癌细胞中的自发及5-氮杂胞苷诱导的重新表达
Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells.
作者信息
Delers A, Szpirer J, Szpirer C, Saggioro D
出版信息
Mol Cell Biol. 1984 Apr;4(4):809-12. doi: 10.1128/mcb.4.4.809-812.1984.
Abstract
Rat hepatoma cells that do not synthesize the hepatic enzyme ornithine carbamoyl transferase spontaneously give rise to producing cells at a low frequency. Reexpression of this differentiation trait is strongly increased by 5-azacytidine treatment, suggesting that hypermethylation plays a critical role in the impaired expression of the ornithine carbamoyl transferase gene in hepatoma cells.
摘要
不合成肝脏酶鸟氨酸氨甲酰基转移酶的大鼠肝癌细胞会以低频率自发产生能合成该酶的细胞。用5-氮杂胞苷处理可显著增强这种分化特性的重新表达，这表明高甲基化在肝癌细胞中鸟氨酸氨甲酰基转移酶基因表达受损中起关键作用。
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