Evans S W, Feizi T, Childs R, Ling N R
Mol Immunol. 1983 Oct;20(10):1127-31. doi: 10.1016/0161-5890(83)90122-0.
A monoclonal antibody has been raised against a cross-reactive idiotypic determinant expressed on human autoantibodies with anti-I and -i specificities. The McAb is directed against a conformational epitope requiring interaction of H- and L-chains for maximal expression. This epitope was strongly expressed on the monoclonal protein of one out of 100 patients with paraproteinaemia and the peripheral blood lymphocytes of one out of 50 cases of B-cell leukaemia. A small amount of the epitope is detectable among immunoglobulins in normal serum.
已制备出一种单克隆抗体，它针对在具有抗I和抗i特异性的人自身抗体上表达的交叉反应性独特型决定簇。该单克隆抗体针对一种构象表位，该表位需要重链和轻链相互作用才能最大程度表达。在100例副蛋白血症患者中的1例的单克隆蛋白以及50例B细胞白血病患者中的1例的外周血淋巴细胞上，该表位强烈表达。在正常血清的免疫球蛋白中可检测到少量该表位。
