与神经病变相关的IgM单克隆蛋白独特型决定簇的研究。
Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.
作者信息
Evans S W, Gregson N A, Leibowitz S L, Ling N R
出版信息
Clin Exp Immunol. 1984 Sep;57(3):621-5.
Abstract
Occasionally IgM monoclonal proteins (MP) from benign gammopathies bind neural antigens and have been associated with demyelinating peripheral neuropathy. A monoclonal antibody (McAb) has been raised against a cross-reactive idiotypic determinant expressed by three out of 12 MP with specificity for neural antigens. The determinant recognised by this MoAb is only expressed when both H and L chain are properly associated. The idiotypic determinant was not expressed by 130 MP randomly selected from patients without neuropathy nor in polyclonal immunoglobulin preparations obtained from healthy individuals.
摘要
偶尔，来自良性丙种球蛋白病的IgM单克隆蛋白（MP）会结合神经抗原，并与脱髓鞘性周围神经病相关。已制备出一种单克隆抗体（McAb），该抗体针对12种对神经抗原有特异性的MP中的3种所表达的交叉反应性独特型决定簇。只有当重链和轻链正确结合时，这种单克隆抗体识别的决定簇才会表达。从无神经病患者中随机选取的130种MP以及从健康个体获得的多克隆免疫球蛋白制剂中均未表达该独特型决定簇。
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