Andrezik J A, Dormer K J, Foreman R D, Person R J
Neuroscience. 1984 Feb;11(2):497-507. doi: 10.1016/0306-4522(84)90040-x.
Efferent connections from a portion of the cerebellar fastigial nucleus were investigated using autoradiography. Bipolar stimulating electrodes were placed in the fastigial nucleus of anesthetized beagles and the area that produced increases in blood pressure and heart rate was localized. A mixture of [3H]leucine and [3H]proline (4:1) was injected into the area and autoradiograms of transported material were prepared. Injections filled the rostral and various parts of the caudal fastigial nucleus. Labeled axons reached the brain stem via two routes, the ipsilateral juxtarestiform body and the contralateral uncinate fasciculus. Ventral portions of the lateral vestibular nucleus were labeled bilaterally, projections to the inferior vestibular and medial vestibular nuclei are contralateral. Nucleus tractus solitarius was heavily labeled on the side opposite the injection. The contralateral medial reticular formation contained many labeled terminals and axons. Label was found in the nucleus reticularis ventralis, lateral reticular nucleus, nucleus gigantocellularis, nucleus pontis caudalis and the paramedian reticular nucleus. No terminal labeling was found in nucleus parvocellularis or nucleus ambiguous. Stimulation of the rostral fastigial nucleus produces increases in blood pressure and heart rate by generalized sympathoexcitation. Many cell groups which facilitate the activity of preganglionic sympathetic neurons do not receive direct fastigial input. It is suggested that that sympathoexcitation resulting from stimulation of the fastigial nucleus occurs through multisynaptic connections in the brain stem.
采用放射自显影法研究了小脑顶核部分的传出联系。将双极刺激电极置于麻醉的比格犬的顶核中，定位引起血压和心率升高的区域。将[3H]亮氨酸和[3H]脯氨酸的混合物（4:1）注入该区域，并制备转运物质的放射自显影片。注射填充了顶核的嘴侧和尾侧的各个部分。标记的轴突通过两条途径到达脑干，即同侧的近髓帆和对侧的钩束。双侧前庭外侧核的腹侧部分被标记，向下前庭核和内侧前庭核的投射是对侧的。孤束核在注射对侧被大量标记。对侧内侧网状结构含有许多标记的终末和轴突。在腹侧网状核、外侧网状核、巨细胞网状核、脑桥尾侧核和旁正中网状核中发现了标记。在小细胞网状核或疑核中未发现终末标记。刺激嘴侧顶核通过全身性交感神经兴奋使血压和心率升高。许多促进节前交感神经元活动的细胞群未接受直接的顶核输入。提示顶核刺激引起的交感神经兴奋是通过脑干中的多突触联系发生的。
