Hoshina M, Boothby M R, Hussa R D, Pattillo R A, Camel H M, Boime I
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2504-7. doi: 10.1073/pnas.81.8.2504.
The gene encoding the alpha subunit of human chorionic gonadotropin contains at least two polymorphic sites in its 3' flanking region detected by restriction enzymes HindIII and EcoRI. We used these polymorphic sites as markers of tissue genotype in normal placenta, hydatidiform mole, choriocarcinoma, and peripheral leukocytes. As expected, inheritance patterns of most hydatidiform moles showed only a paternal genetic contribution. However, one uncommon DNA polymorphism pattern, homozygosity for the absence of the EcoRI site and the presence of the HindIII site, predominated in choriocarcinoma. Thus, our results suggest that moles which have this uncommon polymorphism pattern appear particularly likely to develop into choriocarcinoma.
编码人绒毛膜促性腺激素α亚基的基因在其3'侧翼区含有至少两个可被限制性内切酶HindIII和EcoRI检测到的多态性位点。我们将这些多态性位点用作正常胎盘、葡萄胎、绒毛膜癌和外周血白细胞中组织基因型的标志物。正如预期的那样，大多数葡萄胎的遗传模式仅显示父系遗传贡献。然而，一种不常见的DNA多态性模式，即EcoRI位点缺失和HindIII位点存在的纯合性，在绒毛膜癌中占主导地位。因此，我们的结果表明，具有这种不常见多态性模式的葡萄胎似乎特别容易发展为绒毛膜癌。
