人绒毛膜促性腺激素α亚基的表达与人细胞杂交瘤中的致瘤性表达特异性相关。
Expression of the alpha subunit of human chorionic gonadotropin is specifically correlated with tumorigenic expression in human cell hybrids.
作者信息
Stanbridge E J, Rosen S W, Sussman H H
出版信息
Proc Natl Acad Sci U S A. 1982 Oct;79(20):6242-5. doi: 10.1073/pnas.79.20.6242.
Abstract
The expression of HeLa parent phenotype protein markers, the alpha subunit of human chorionic gonadotropin and placental alkaline phosphatase isoenzymes, has been evaluated in paired tumorigenic and nontumorigenic HeLa-fibroblast human cell hybrids. Both of these proteins have been used clinically as markers of malignancy. The results showed that both are expressed in the hybrids. Expression of the gonadotropin subunit in the hybrids is specifically correlated with tumorigenicity; the placental alkaline phosphatase isoenzyme showed no such correlation and was expressed in both tumorigenic and nontumorigenic hybrids.
摘要
在成对的致瘤性和非致瘤性人HeLa-成纤维细胞杂交细胞中，对HeLa亲本表型蛋白标志物、人绒毛膜促性腺激素α亚基和胎盘碱性磷酸酶同工酶的表达进行了评估。这两种蛋白质在临床上都被用作恶性肿瘤的标志物。结果表明，这两种蛋白在杂交细胞中均有表达。杂交细胞中促性腺激素亚基的表达与致瘤性具有特异性相关性；胎盘碱性磷酸酶同工酶则无此相关性，在致瘤性和非致瘤性杂交细胞中均有表达。
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