Wang C L, Kaplan H J, Waldrep J C, Pulliam M
Retina. 1983 Fall-Winter;3(4):249-52. doi: 10.1097/00006982-198300340-00002.
Unilateral acute retinal necrosis (ARN), developed in a previously healthy 17-year-old boy. Neovascularization of the retina and optic disc was observed when the opaque vitreous was removed by pars plana vitrectomy. Following surgery there was a rapid resolution of neovascularization suggesting that intraocular inflammation, rather than retinal ischemia, was the cause of new vessel formation. Analysis of vitreous mononuclear cells with monoclonal antibodies and the fluorescence-activated cell sorter (FACS) revealed mostly T cells; a pattern consistent with intraocular infection as the cause of ARN. The pathogenesis of intraocular infection is complex and some patients with ARN may be helped by systemic immunosuppression (ie, corticosteroids).
一名既往健康的17岁男孩发生了单侧急性视网膜坏死（ARN）。在通过玻璃体平坦部玻璃体切除术清除不透明玻璃体时，观察到视网膜和视盘出现新生血管。手术后，新生血管迅速消退，这表明眼内炎症而非视网膜缺血是新血管形成的原因。用单克隆抗体和荧光激活细胞分选仪（FACS）对玻璃体单核细胞进行分析，结果显示主要为T细胞；这一模式与ARN由眼内感染引起相一致。眼内感染的发病机制很复杂，一些ARN患者可能受益于全身免疫抑制（即使用皮质类固醇）。
