Lindner G
Z Mikrosk Anat Forsch. 1984;98(1):107-18.
The effect of peptides (SP1-2, SP3-4 and SP5-11) of substance P (SP1-11) on the morphology of the areas of growth of explants of the ganglion trigeminale from chick embryos after incubation in Maximow chambers was observed. N- and C-terminal sequences effected the growth of cultures differently. In dipeptide-treated (= N-terminal sequences) cultures the areas of growth increased. In heptapeptide-treated cultures (= C-terminal sequence SP5-11) the areas of growth decreased. Only the dipeptide SP3-4 effects a mitogenic effect on nonneuronal cells in short time tests. The C-terminal sequence SP5-11 stimulates neither the growth of nerve fibres nor the proliferation of cells. Finally the importance of this in-vitro-tests in relation to the in-vivo-situation is discussed.
观察了P物质（SP1-11）的肽段（SP1-2、SP3-4和SP5-11）对鸡胚三叉神经节外植体在Maximow培养箱中孵育后生长区域形态的影响。N端和C端序列对培养物生长的影响不同。在二肽处理（=N端序列）的培养物中，生长区域增加。在七肽处理（=C端序列SP5-11）的培养物中，生长区域减少。只有二肽SP3-4在短时间试验中对非神经元细胞有促有丝分裂作用。C端序列SP5-11既不刺激神经纤维生长也不刺激细胞增殖。最后讨论了这种体外试验相对于体内情况的重要性。
