Malina H Z
Acta Microbiol Pol. 1983;32(4):353-62.
The process of cephamycin biosynthesis by S. griseus and S. lactamdurans strains was investigated. The antibiotic activities of both strains in thirteen media elaborated in our laboratory were compared with those in nine media described in the literature. The best medium was that one which contained 20 g/dcm3 of glucose and 30 g/dcm3 of corn steep liquor. In this medium after a two stage shaken culture fermentation both strains showed specific growth rate from 0.027 to 0.034 h-1 and biomass yield about 5 g of dry weight per 1 dcm3. Under these conditions the highest activity was achieved after 96 hours of the fermentation.
研究了灰色链霉菌和内酰胺链霉菌菌株合成头孢霉素的过程。将这两种菌株在我们实验室配制的13种培养基中的抗生素活性与文献中描述的9种培养基中的活性进行了比较。最佳培养基是含有20 g/dcm³葡萄糖和30 g/dcm³玉米浆的培养基。在该培养基中进行两阶段摇瓶培养发酵后，两种菌株的比生长速率为0.027至0.034 h⁻¹，生物量产量约为每1 dcm³ 5 g干重。在这些条件下，发酵96小时后活性最高。
