Yamamoto B K, Freed C R
Brain Res. 1984 Apr 9;297(1):115-9. doi: 10.1016/0006-8993(84)90547-x.
The trained circling rat model was used to investigate dopamine and serotonin metabolism in extrapyramidal and limbic structures during turning behavior. We have previously reported that dopamine turnover is increased during circling in the caudate contralateral to the circling direction in this behavioral model. We have now studied changes in dopamine and serotonin turnover in nucleus accumbens, substantia nigra and amygdala. As in the caudate, dopamine production in nucleus accumbens was selectively increased on the contralateral side after 20 min of circling. By contrast, dopamine turnover in substantia nigra exhibited a relative decline on the contralateral side. Dopamine synthesis in the amygdala was not affected by circling. Selective changes in serotonin metabolism were also seen in these brain regions. In caudate and accumbens, serotonin turnover was unaffected by circling. However, both substantia nigra and amygdala showed significant, progressive increases in serotonin metabolism in the contralateral side after 20 and 70 min of circling. These results show that extrapyramidal and limbic dopamine and serotonin metabolism are involved in turning behavior of normal animals. Multiple transmitters of the nigrostriatal pathway and the limbic system appear to interact to modulate voluntary circling behavior.
训练有素的转圈大鼠模型用于研究旋转行为期间锥体外系和边缘系统结构中的多巴胺和血清素代谢。我们之前曾报道，在此行为模型中，与旋转方向对侧的尾状核在旋转过程中多巴胺周转增加。我们现在研究了伏隔核、黑质和杏仁核中多巴胺和血清素周转的变化。与尾状核一样，旋转20分钟后，伏隔核中多巴胺的生成在对侧选择性增加。相比之下，黑质中多巴胺周转在对侧呈现相对下降。杏仁核中的多巴胺合成不受旋转影响。在这些脑区也观察到血清素代谢的选择性变化。在尾状核和伏隔核中，血清素周转不受旋转影响。然而，在旋转20分钟和70分钟后，黑质和杏仁核在对侧均显示出血清素代谢显著、进行性增加。这些结果表明，锥体外系和边缘系统的多巴胺和血清素代谢参与正常动物的旋转行为。黑质纹状体通路和边缘系统的多种递质似乎相互作用以调节自主旋转行为。
