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神经细胞黏附分子L1与表面抗原BSP-2和D2的N-CAM相关组不同。

The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2.

作者信息

Faissner A, Kruse J, Goridis C, Bock E, Schachner M

出版信息

EMBO J. 1984 Apr;3(4):733-7. doi: 10.1002/j.1460-2075.1984.tb01876.x.

DOI:10.1002/j.1460-2075.1984.tb01876.x
PMID:6202513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557418/
Abstract

The neural cell adhesion molecule L1 and the group of N-CAM related molecules, BSP-2 and D2 antigen, are immunochemically distinct molecular species. The two groups of surface molecules are also functionally distinct entities, since inhibition of Ca2+-independent adhesion among early post-natal mouse cerebellar cells by Fab fragments of both antibodies are at least additive, when compared with equal concentrations of the individual antibodies.

摘要

神经细胞黏附分子L1以及与N-CAM相关的分子组，即BSP-2和D2抗原，是免疫化学上不同的分子种类。这两组表面分子在功能上也是不同的实体，因为与相同浓度的单个抗体相比，两种抗体的Fab片段对出生后早期小鼠小脑细胞间非钙依赖性黏附的抑制作用至少是相加的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/044979cea8e0/emboj00308-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/a050661a4129/emboj00308-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/c0b20497f60a/emboj00308-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/b33d15236d44/emboj00308-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/180d00743aa3/emboj00308-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/d0c01d8ef50c/emboj00308-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/044979cea8e0/emboj00308-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/a050661a4129/emboj00308-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/c0b20497f60a/emboj00308-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/b33d15236d44/emboj00308-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/180d00743aa3/emboj00308-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/d0c01d8ef50c/emboj00308-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e2/557418/044979cea8e0/emboj00308-0049-b.jpg

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1
The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2.神经细胞黏附分子L1与表面抗原BSP-2和D2的N-CAM相关组不同。
EMBO J. 1984 Apr;3(4):733-7. doi: 10.1002/j.1460-2075.1984.tb01876.x.
2
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J Neurosci. 1986 Feb;6(2):605-12. doi: 10.1523/JNEUROSCI.06-02-00605.1986.
4
Molecular heterogeneity and structural evolution during cerebellar ontogeny detected by monoclonal antibody of the mouse cell surface antigen BSP-2.通过小鼠细胞表面抗原BSP-2单克隆抗体检测到的小脑个体发生过程中的分子异质性和结构演变
Brain Res. 1983 Apr 11;265(1):87-100. doi: 10.1016/0006-8993(83)91337-9.
5
Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration.一种参与神经元迁移的新型神经胶质细胞黏附分子的生化与功能特性
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6
Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules.神经细胞黏附分子关键结构与结合功能的进化保守性
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6881-5. doi: 10.1073/pnas.81.21.6881.
7
The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.神经细胞黏附分子N-CAM增强了依赖L1的细胞间相互作用。
J Cell Biol. 1990 Jan;110(1):193-208. doi: 10.1083/jcb.110.1.193.
8
Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion.一种参与细胞黏附的新型神经元细胞表面成分（L1抗原）的免疫细胞化学和生化特性
EMBO J. 1984 Jan;3(1):1-10. doi: 10.1002/j.1460-2075.1984.tb01753.x.
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Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies.L1、L2和N-CAM抗体对神经元-神经元、神经元-星形胶质细胞以及星形胶质细胞-星形胶质细胞黏附的差异性抑制作用。
Nature. 1985;316(6030):728-30. doi: 10.1038/316728a0.
10
Immunocytological localization of cell adhesion molecules L1 and N-CAM and the shared carbohydrate epitope L2 during development of the mouse neocortex.小鼠新皮质发育过程中细胞黏附分子L1、N-CAM及共享碳水化合物表位L2的免疫细胞定位
Brain Res. 1986 Jan;389(1-2):153-67. doi: 10.1016/0165-3806(86)90183-5.

引用本文的文献

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本文引用的文献

1
Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture.肌束颤动对培养的脊髓神经节神经突生长的影响。
J Cell Biol. 1980 Nov;87(2 Pt 1):370-8. doi: 10.1083/jcb.87.2.370.
2
Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide.一种神经细胞表面抗原的组织和发育阶段特异性形式，与一种共同多肽的糖基化差异相关。
EMBO J. 1982;1(10):1239-44. doi: 10.1002/j.1460-2075.1982.tb00019.x.
3
Purification of the synaptic membrane glycoprotein D2 from rat brain.
神经细胞黏附分子（NCAM）的第四个免疫球蛋白样结构域包含一个用于寡甘露糖型聚糖的碳水化合物识别结构域，该结构域与L1和神经突生长相关。
J Cell Biol. 1993 Jun;121(6):1409-21. doi: 10.1083/jcb.121.6.1409.
4
Biosynthesis and membrane topography of the neural cell adhesion molecule L1.神经细胞黏附分子L1的生物合成与膜拓扑结构
EMBO J. 1985 Dec 1;4(12):3105-13. doi: 10.1002/j.1460-2075.1985.tb04052.x.
5
Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development.神经细胞黏附分子N-CAM的180-kD成分在发育过程中的选择性表达。
J Cell Biol. 1985 Nov;101(5 Pt 1):1921-9. doi: 10.1083/jcb.101.5.1921.
6
Specific regulation of N-CAM/D2-CAM cell adhesion molecule during skeletal muscle development.骨骼肌发育过程中N-CAM/D2-CAM细胞粘附分子的特异性调控
EMBO J. 1985 Mar;4(3):623-30. doi: 10.1002/j.1460-2075.1985.tb03675.x.
7
Membrane glycoproteins involved in neurite fasciculation.参与神经突成束的膜糖蛋白。
J Cell Biol. 1987 Feb;104(2):343-53. doi: 10.1083/jcb.104.2.343.
8
Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle.几种黏附大分子（神经细胞黏附分子、L1、J1、NILE、桥粒芯糖蛋白、层粘连蛋白、纤连蛋白和一种硫酸乙酰肝素蛋白聚糖）在胚胎、成年和去神经支配的成年骨骼肌中的表达。
J Cell Biol. 1986 Feb;102(2):420-31. doi: 10.1083/jcb.102.2.420.
9
Characterization of the cell adhesion molecules L1, N-CAM and J1 in the mouse intestine.小鼠肠道中细胞粘附分子L1、N-CAM和J1的特性分析
EMBO J. 1987 Sep;6(9):2581-6. doi: 10.1002/j.1460-2075.1987.tb02548.x.
10
The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions.神经细胞黏附分子N-CAM的180-kD成分参与细胞间接触和细胞骨架-膜相互作用。
Cell Tissue Res. 1987 Oct;250(1):227-36. doi: 10.1007/BF00214676.
从大鼠脑中纯化突触膜糖蛋白D2。
Scand J Immunol. 1982 Feb;15(2):179-85. doi: 10.1111/j.1365-3083.1982.tb00636.x.
4
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.从胚胎脑膜中纯化的神经细胞黏附分子的化学特性分析。
J Biol Chem. 1982 Jul 10;257(13):7720-9.
5
In vitro reaggregation of dissociated mouse cerebellar cells. I. Demonstration of different aggregation mechanisms.解离的小鼠小脑细胞的体外再聚集。I. 不同聚集机制的证明。
Exp Cell Res. 1982 Jun;139(2):285-96. doi: 10.1016/0014-4827(82)90253-1.
6
A dot-immunobinding assay for monoclonal and other antibodies.一种用于单克隆抗体及其他抗体的斑点免疫结合测定法。
Anal Biochem. 1982 Jan 1;119(1):142-7. doi: 10.1016/0003-2697(82)90677-7.
7
Neural cell adhesion molecules in rodent brains isolated by monoclonal antibodies with cross-species reactivity.
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4234-8. doi: 10.1073/pnas.79.13.4234.
8
Monoclonal antibody against cell surface glycoprotein of neurons.抗神经元细胞表面糖蛋白的单克隆抗体。
Brain Res. 1981 Jun 15;214(2):433-9. doi: 10.1016/0006-8993(81)91208-7.
9
The nervous system specific protein D2 is involved in adhesion among neurites from cultured rat ganglia.神经系统特异性蛋白D2参与培养的大鼠神经节神经突之间的黏附。
FEBS Lett. 1980 Feb 25;111(1):39-42. doi: 10.1016/0014-5793(80)80756-3.
10
Adult and embryonic mouse neural cell adhesion molecules have different binding properties.成年和胚胎小鼠神经细胞黏附分子具有不同的结合特性。
Nature. 1983;304(5924):347-9. doi: 10.1038/304347a0.