Gandolfo G M, De Angelis A, Torresi M V
Haemostasis. 1980;9(1):15-9. doi: 10.1159/000214336.
Antithrombin III activity was determined by three techniques in 58 patients with maturity onset diabetes mellitus: a spectrophotometric assay, using the chromogenic substrate Chromozym TH; evaluation of antifactor Xa activity and an immunochemical technique. Although the biological antithrombin III activity was clearly reduced in individual subjects, there was only a slight nonsignificant reduction in the mean anti-thrombin III activity values as compared to normal subjects. No difference was observed between diabetics receiving insulin and subjects taking oral hypoglycemic agents or between diabetics without vascular complications and diabetics with vascular lesions.
采用三种技术对58例成年型糖尿病患者的抗凝血酶III活性进行了测定：使用发色底物Chromozym TH的分光光度法、抗Xa因子活性评估以及免疫化学技术。尽管个别患者的生物抗凝血酶III活性明显降低，但与正常受试者相比，平均抗凝血酶III活性值仅有轻微的、无统计学意义的降低。接受胰岛素治疗的糖尿病患者与服用口服降糖药的患者之间，以及无血管并发症的糖尿病患者与有血管病变的糖尿病患者之间均未观察到差异。
