糖尿病视网膜病变中的血小板功能：β-血小板球蛋白和血小板因子4水平

Platelet function in diabetic retinopathy: levels of beta-thromboglobulin and platelet factor 4.

作者信息

Fenández-Vigo J, Cordido M, Fernández Sabugal J, Cordido F

机构信息

University of Extremadura, Department of Ophthalmology, Badajoz, Spain.

出版信息

Metab Pediatr Syst Ophthalmol (1985). 1992;15(1-3):5-8.

PMID:1484500

Abstract

Altered platelet function has been reported in diabetic patients. This article reports plasma levels of beta-thromboglobulin and platelet factor 4 as measures of in vivo platelet activity in diabetic and control groups. Both beta-thromboglobulin and platelet factor 4 were significantly higher in diabetics than in controls (p < 0.01). The levels observed were not significantly affected by age, sex, diabetes type or whether the diabetic had nonproliferative or proliferative retinopathy, but beta-thromboglobulin levels were significantly higher in diabetics of less than 10 years standing than in those who had suffered diabetes for over 20 years (p < 0.05).

摘要

据报道，糖尿病患者存在血小板功能改变。本文报告了β-血小板球蛋白和血小板因子4的血浆水平，以此作为糖尿病组和对照组体内血小板活性的指标。糖尿病患者的β-血小板球蛋白和血小板因子4水平均显著高于对照组（p < 0.01）。观察到的水平不受年龄、性别、糖尿病类型或糖尿病患者是否患有非增殖性或增殖性视网膜病变的显著影响，但病程少于10年的糖尿病患者的β-血小板球蛋白水平显著高于病程超过20年的患者（p < 0.05）。