Aguirre P, Scully R E, Dayal Y, DeLellis R A
Am J Surg Pathol. 1984 May;8(5):345-56. doi: 10.1097/00000478-198405000-00003.
Forty-five cases of mucinous tumors of the ovary were studied for argyrophilia. Argyrophil cells were identified in seven of the 22 cystadenomas (32%), five of the 11 borderline tumors (45%), and two of the 12 carcinomas (17%). These 14 tumors and two additional mucinous tumors known to contain argyrophil cells were studied further by immunohistochemical methods for the localization of calcitonin, gastrin, somatostatin, adrenocorticotropin (ACTH), serotonin, neurotensin, and lysozyme. Serotonin immuno-reactivity was identified in 15 of the 16 cases. Among the peptide hormones, there was a high frequency of positivity for ACTH, gastrin, and somatostatin. Despite the demonstration of reactivity for these hormones, there was no clinical evidence of syndromes of hormone excess in the patients. Lysozyme was present in all but one of the benign and borderline tumors, but was not identified in the carcinomas. Lysozyme was also found in normal and neoplastic gastric and endocervical epithelium, indicating that its presence is not useful in differentiating gastrointestinal and müllerian-type epithelium. The results of this study confirm the previously recognized intestinal characteristics of the epithelium of many mucinous tumors, but also raise the question whether the simple, uniformly mucinous epithelium that is most common within these tumors and is generally regarded as endocervical in type may occasionally be gastric in nature.
对45例卵巢黏液性肿瘤进行了嗜银性研究。在22例囊腺瘤中有7例（32%）发现嗜银细胞，11例交界性肿瘤中有5例（45%），12例癌中有2例（17%）。对这14例肿瘤以及另外2例已知含有嗜银细胞的黏液性肿瘤，进一步采用免疫组织化学方法研究降钙素、胃泌素、生长抑素、促肾上腺皮质激素（ACTH）、5-羟色胺、神经降压素和溶菌酶的定位。16例中有15例发现5-羟色胺免疫反应性。在肽类激素中，ACTH、胃泌素和生长抑素的阳性频率较高。尽管证实了这些激素的反应性，但患者并无激素过多综合征的临床证据。除1例良性和交界性肿瘤外，其余所有肿瘤均有溶菌酶存在，但在癌中未发现。在正常和肿瘤性胃及宫颈内膜上皮中也发现了溶菌酶，这表明其存在无助于区分胃肠道和苗勒氏型上皮。本研究结果证实了许多黏液性肿瘤上皮细胞先前已被认识到的肠型特征，但也提出了一个问题，即这些肿瘤中最常见的、通常被认为是宫颈内膜型的简单、均匀的黏液上皮细胞，其性质是否偶尔可能是胃型的。
