一种针对马来布鲁线虫微丝蚴表面抗原的单克隆抗体可降低感染沙鼠的微丝蚴血症。
A monoclonal antibody to surface antigens on microfilariae of Brugia malayi reduces microfilaremia in infected jirds.
作者信息
Canlas M, Wadee A, Lamontagne L, Piessens W F
出版信息
Am J Trop Med Hyg. 1984 May;33(3):420-4. doi: 10.4269/ajtmh.1984.33.420.
PMID:6203419
Abstract
A monoclonal antibody to surface antigens of Brugia malayi microfilariae promotes the adherence of peripheral blood cells to microfilariae in vitro and reduces microfilaremia in vivo. The antibody reacts with epitopes present on two stage-specific antigens with estimated molecular weights of 70,000 and 75,000 daltons.
摘要
一种针对马来布鲁线虫微丝蚴表面抗原的单克隆抗体，在体外可促进外周血细胞与微丝蚴的黏附，并在体内降低微丝蚴血症。该抗体与两种阶段特异性抗原上的表位发生反应，这两种抗原的估计分子量分别为70,000和75,000道尔顿。
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