Linnoila M, Miller T L, Bartko J, Potter W Z
Arch Gen Psychiatry. 1984 Jul;41(7):688-92. doi: 10.1001/archpsyc.1984.01790180058007.
The 24-hour urinary serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) outputs were repeatedly measured in 21 patients with major affective disorders after a minimum of three weeks free of drug treatments and at steady state during subsequent antidepressant treatments or during the second week after a series of electroconvulsive treatments (ECTs). The 5-HIAA outputs were more variable over time than the outputs of major catecholamine metabolites, previously studied by us. Patients with rapid mood cycles excreted large amounts of 5-HT. Lithium carbonate and ECTs reduced the outputs of 5-HT and 5-HIAA, respectively. Lithium carbonate also stabilized the output of 5-HT. No common effect of different antidepressant treatments on indole outputs was found.
在21例重度情感障碍患者中，在至少停药三周后以及后续抗抑郁治疗稳定期或一系列电休克治疗（ECT）后的第二周，反复测量其24小时尿中血清素（5-HT）和5-羟吲哚乙酸（5-HIAA）的排出量。与我们之前研究的主要儿茶酚胺代谢产物的排出量相比，5-HIAA的排出量随时间变化更大。情绪快速循环的患者排出大量的5-HT。碳酸锂和ECT分别降低了5-HT和5-HIAA的排出量。碳酸锂还稳定了5-HT的排出量。未发现不同抗抑郁治疗对吲哚排出量有共同影响。
