关于轴突导向的体外实验表明，视顶盖存在前后梯度。
In vitro experiments on axon guidance demonstrating an anterior-posterior gradient on the tectum.
作者信息
Bonhoeffer F, Huf J
出版信息
EMBO J. 1982;1(4):427-31. doi: 10.1002/j.1460-2075.1982.tb01186.x.
Abstract
Axonal growth cones originating from explants of embryonic chick retina were simultaneously exposed to two different cell monolayers and their preference for particular monolayers as a substrate for growth was determined. These experiments show that: (1) nasal retinal axons can distinguish between retinal and tectal cells; (2) temporal retinal axons can distinguish between tectal cells that originated from different positions within the tectum along the antero-posterior axis; (3) axons originating from nasal parts of the retina have different recognizing capabilities from temporal axons; (4) the property of the tectal cells, which is attractive for temporal axons, has a graded distribution along the antero-posterior axis of the tectum; and (5) this gradient also exists in non-innervated tecta.
摘要
源自胚胎鸡视网膜外植体的轴突生长锥同时暴露于两种不同的细胞单层，并确定它们对特定单层作为生长底物的偏好。这些实验表明：（1）鼻侧视网膜轴突能够区分视网膜细胞和顶盖细胞；（2）颞侧视网膜轴突能够区分沿前后轴起源于顶盖内不同位置的顶盖细胞；（3）起源于视网膜鼻侧部分的轴突与颞侧轴突具有不同的识别能力；（4）对颞侧轴突具有吸引力的顶盖细胞特性沿顶盖的前后轴呈梯度分布；（5）这种梯度在未受神经支配的顶盖中也存在。
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