Gottlieb D I, Rock K, Glaser L
Proc Natl Acad Sci U S A. 1976 Feb;73(2):410-4. doi: 10.1073/pnas.73.2.410.
Cell-cell adhesion was examined in the developing chick neural retina. A dorsoventral gradient of adhesive specificity in dissociated cells was detected which exhibits a complementarity such that the highest cell-cell affinities are exhibited between cells derived from the extremes of the gradient. If a nasotemporal gradient exists it must exhibit significantly lower cell-cell affinity. The relevance of these findings to pattern formation in the nervous system is discussed.
在发育中的鸡神经视网膜中检测细胞间黏附。在解离的细胞中检测到黏附特异性的背腹梯度,该梯度表现出互补性,使得在源自梯度两端的细胞之间表现出最高的细胞间亲和力。如果存在鼻颞梯度,那么它必须表现出明显更低的细胞间亲和力。本文讨论了这些发现与神经系统模式形成的相关性。