Immunogenicity of galactosylated liposomes.

The kinetics of the immune response to galactosylated liposomes in saline was studied in rabbits. The antibody level in the secondary immunization was found to be higher compared to that in the primary response. The antibodies were purified on an immunoadsorbent column of galactosylated bovine serum albumin. Anti-galactosyl antibodies belonged to both IgM and IgG classes, the former being the major fraction. Both failed to agglutinate normal or neuraminidase treated human or rabbit erythrocytes but they agglutinated trypsinized cells.