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伪麻黄碱与曲普利啶单独及联合治疗变应性鼻炎的双盲交叉研究(作者译)

[Double blind crossover study of pseudoephedrine and triprolidine alone and in combination in the treatment of allergic rhinitis (author's transl)].

作者信息

Empey D W, Bye C, Hodder M, Hughes D T

出版信息

Prensa Med Mex. 1975 Nov-Dec;40(11-12):383-8.

PMID:772669
Abstract

In a double-blind crossover trial of pseudoephedrine 60 mg. and triprolidine 2.5 mg. alone and in combination, on 40 volunteers suffering from allergic rhinitis, both drugs were found superior to placebo in reducing the effects of allergic rhinitis and were of equal efficacy. The combination tablet was consistently better than either drug in several of the assessments and was the treatment which the subjects, as a whole, preferred. Side effects were not a problem with any of the medications.

摘要

在一项针对40名过敏性鼻炎志愿者的双盲交叉试验中,分别对单独使用60毫克伪麻黄碱和2.5毫克曲普利啶以及二者联合使用的效果进行了测试。结果发现,两种药物在减轻过敏性鼻炎症状方面均优于安慰剂,且疗效相当。在多项评估中,复方片剂始终比任何一种单一药物的效果更好,是受试者总体上更倾向选择的治疗方式。所有药物均未出现副作用问题。

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