Faktor V M, Shipova L Ia
Biull Eksp Biol Med. 1984 Jun;97(6):710-3.
The DNA content was measured in the cells of 37 well-differentiated spontaneous hepatomas from 20 CBA mice aged 18 to 22 months. In all the cases, the DNA distribution pattern was polymodal, with the class of tetraploid cells being predominant. It was independent of the tumor ability to produce AFP. No signs of aneuploidy were noted. The cells of spontaneous hepatomas were characterized by a high level of polyploidy and by a dramatic reduction in the number of binuclear cells as compared with liver cells. A tendency was recorded toward positive correlation between the degree of cellular polyploidy and tumor size. The high level of polyploidy seen in spontaneous hepatomas which is also characteristic of the normal liver is considered to be a sign of tumor maturity.
对来自20只18至22个月龄CBA小鼠的37个高分化自发性肝癌细胞进行了DNA含量测定。在所有病例中，DNA分布模式呈多峰型，四倍体细胞类为主。它与肿瘤产生甲胎蛋白的能力无关。未发现非整倍体迹象。与肝细胞相比，自发性肝癌细胞的特征是多倍体水平高，双核细胞数量显著减少。记录到细胞多倍体程度与肿瘤大小之间呈正相关趋势。自发性肝癌中所见的高多倍体水平也是正常肝脏的特征，被认为是肿瘤成熟的标志。
