Young S N, Gauthier S, Kiely M E, Lal S, Brown G M
Neuroendocrinology. 1984 Jul;39(1):87-92. doi: 10.1159/000123961.
Melatonin was given orally to patients undergoing diagnostic pneumoencephalography and various compounds were measured in the lumbar and cisternal CSF. Melatonin markedly increased plasma and CSF melatonin concentrations. The plasma: CSF melatonin ratios were similar in patients who received, and in those who did not receive, melatonin. This supports the idea that melatonin is released from pineal to blood and gets into the CSF via the blood. Melatonin did not affect CSF 5-hydroxyindoleacetic acid, which indicates that it has no effect on 5-hydroxytryptamine metabolism. Melatonin increased CSF indoleacetic acid significantly, indicating increased metabolism of tryptamine. Melatonin did not affect CSF cAMP levels, but increased cGMP levels. The effect on indoleacetic acid and cGMP was seen in both lumbar and cisternal CSF, suggesting that melatonin can have generalized actions throughout the CNS.
对接受诊断性气脑造影的患者口服褪黑素，并检测腰段和脑池脑脊液中的各种化合物。褪黑素显著提高了血浆和脑脊液中褪黑素的浓度。接受和未接受褪黑素的患者血浆与脑脊液中褪黑素的比值相似。这支持了褪黑素从松果体释放到血液中并通过血液进入脑脊液的观点。褪黑素不影响脑脊液中5-羟吲哚乙酸，这表明它对5-羟色胺代谢没有影响。褪黑素显著增加脑脊液中吲哚乙酸，表明色胺代谢增加。褪黑素不影响脑脊液中环磷酸腺苷（cAMP）水平，但增加环磷酸鸟苷（cGMP）水平。在腰段和脑池脑脊液中均观察到对吲哚乙酸和cGMP的影响，表明褪黑素可在整个中枢神经系统产生广泛作用。
